食事からの無機ヒ素摂取量と健康リスク

抄録

Dietary intake of inorganic arsenic (iAs) was estimated by market basket method. One hundred and fifty-two food samples were collected in Shizuoka city in 2015 and food composites of 17 categories were prepared based on the National Health and Nutrition Survey results. Arsenic speciation analysis (iAs and monomethylarsonic acid, dimethylarsinic acid, and arsenobetaine) of the 17 composites was carried out with high performance liquid chromatography-inductively coupled plasma mass spectrometry after dilute hydrochloric acid extraction. Estimated daily intakes of iAs was 25.4 µg As/person/day or 0.423 µg As/kg body weight/day when average body weight of the Japanese was assumed to be 60 kg. Cereals contributed to daily iAs intake most (64 %) and Algae did the second (27 %). The results are discussed in relation to the literature data on daily iAs intake of the Japanese. Non-cancer risk and cancer risk of the iAs intake were estimated by the updated US EPA Reference Dose (RfD, 0.06µg/kg/day) and Cancer Slope Factor (3.17 × 10^-2 [µg/kg/day]^-1), respectively. Hazard quotient was 7 and cancer risk was calculated to be 1.3 × 10^-3, indicating non-negligible cancer and non-cancer risks. Reduction of iAs intake would be desirable.