EFFECT OF HYPOPHYSECTOMY ON LIVER CATALASE ACTIVITY IN TUMOR-BEARING MICE

抄録

1. An attempt was made to examine whether or not some hypophyseal factors is involved in the control of liver catalase level in tumor-bearing mice, male hybrid mice being used, and hypophysectomy performed with parapharyngeal approach. Catalase activity was estimated by the two methods; iodometry and manometric method. As a transplantable tumor, Ehrlich acsites tumor was used.
2. Hypophysectomy does not increase the liver catalase level in the case of normal mice as opposed to the case of rats. In the hypophysectomized-tumor-bearing mice, however, there was found no increase in liver catalase level in spite of the presence of growing tumor, although in the case of mice with hypophysis intact or with incomplete hypophysis, there was a considerable reduction of liver catalase level as a result of tumor transplantation.
3. The result suggests that hypophysis is indispensable for the reduction of liver catalase in tumor-bearing animals.