GANN Japanese Journal of Cancer Research
Print ISSN : 0016-450X
FORMATION OF 8-HYDROXYGUANINE RESIDUES IN DNA BY X-IRRADIATION
Hiroshi KASAIHiroshi TANOOKASusumu NISHIMURA
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JOURNAL FREE ACCESS

1984 Volume 75 Issue 12 Pages 1037-1039

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Abstract

A new type of ionizing radiation-induced DNA base damage, 8-hydroxyguanine formation, was found in DNA that had been irradiated by X-rays in aqueous solution. The extent of this modification linearly increased with increase in the X-ray dose up to 40 krad. When an OH radical scavenger, ethanol, was added to the DNA solution, the hydroxylation was inhibited almost completely, suggesting that the reaction proceeds via the formation of OH radicals.

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© The Japanese Cancer Association
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