DISRUPTIVE EFFECT OF DIETHYLSTILBESTROL ON MICROTUBULES

Abstract

Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200μM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.