Japanese Journal of Cancer Research GANN
Print ISSN : 0910-5050
RAT PROSTATE AS ONE OF THE TARGET ORGANS FOR 3, 2'-DIMETHYL-4-AMINOBIPHENYL-INDUCED CARCINOGENESIS
EFFECTS OF DIETARY ETHINYL ESTRADIOL AND METHYLTESTOSTERONE
Tomoyuki SHIRAITakao SAKATAShoji FUKUSHIMAEtsuo IKAWANobuyuki ITO
Author information
JOURNAL FREE ACCESS

1985 Volume 76 Issue 9 Pages 803-808

Details
Abstract

Twenty consecutive weekly sc injections of 50mg/kg body weight of 3, 2'-dimethyl-4-aminobiphenyl (DMAB), a multipotential carcinogen, were given to male F344 rats and subsequently groups of animals were treated with dietary ethinyl estradiol (EE, 2.5ppm) or methyltestosterone (MT, 300ppm) for up to 40 weeks. Prostate carcinomas were found in 4 out of 32 rats given DMAB followed by MT and in 2 out of 29 rats given DMAB alone. Atypical hyperplasia of the prostate epithelium in these two groups was found in 22% and 14%, respectively. Neither carcinoma nor atypical hyperplasia was seen in the prostate of animals given DMAB followed by EE. In other organs, tumors were frequently found in the ear duct, skin, and large intestine and less frequently in the lung, preputial glands, small intestine and liver. EE significantly suppressed tumor incidence of the ear duct and sebaceous glands while increasing the incidence of liver tumor and mesothelioma. The present data indicates DMAB to be a useful carcinogen for the induction of prostate carcinomas in rats.

Information related to the author
© The Japanese Cancer Association
Previous article Next article
feedback
Top