Japanese Journal of Cancer Research GANN
Print ISSN : 0910-5050
EFFECTS OF A HIGH-VOLTAGE ELECTRICAL IMPULSE AND AN ANTICANCER DRUG ON IN VIVO GROWING TUMORS
Motonori OKINOHitoshi MOHRI
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1987 年 78 巻 12 号 p. 1319-1321

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Application of a high-voltage electrical impulse (5kV/cm, 2msec) after bleomycin administration resulted in a significant size decrease of subcutaneously inoculated AH-109A hepatocellular carcinoma in Donryu rats. The tumor size decreased to an average of 17% of the initial mass 4 days after the treatment. Neither the high-voltage electrical impulse nor bleomycin administration alone showed an inhibitory effect on the tumor growth. It was concluded that the concomitant use of a high-voltage electrical impulse and an anticancer drug has the potential to be applicable for cancer treatment.

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© The Japanese Cancer Association
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