The Journal of The Japanese Society for Cataract Research
Online ISSN : 2188-613X
Print ISSN : 0915-4302
ISSN-L : 0915-4302
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A Structure-Activity Relationship Study Using Novel Polymethoxylated Flavone for Searching Lead Compounds of Anti-cataract Drug
Yoshiki Miyata
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2017 Volume 29 Issue 1 Pages 7-12

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Abstract

Lens epithelial cells which arranged in a mono-layer and cover the anterior surface of the lens play an important role for maintenance of lens transparency through active energy metabolism. On the other hand, the abnormalities in the growth or production of matrix metalloproteinase (MMP) from lens epithelial cells are involved in fibrotic cataract formations, such as anterior subcapsular cataract and posterior capsular opacification. To propose lead compounds for anti-cataract drug based on novel mechanism, we evaluated the effect of natural polymethoxylated flavone, nobiletin and the newly-synthesized derivatives on cell growth and MMP production in lens epithelial cells.

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© 2017 Japanese Society for Cataract Research
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