The Journal of The Japanese Society for Cataract Research
Online ISSN : 2188-613X
Print ISSN : 0915-4302
ISSN-L : 0915-4302
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The Potential Effects of a Lutein-containing Supplement on Inhibiting the Progression of Cataracts — the Changes of Antioxidant-related Proteins in Aqueous Humor and Lenticular Anterior Capsule of Patients with Cataracts
Rijo Hayashi
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2018 Volume 30 Issue 1 Pages 13-21

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Abstract

Lutein is indicated effective on preventing age-related macular degeneration while epidemiological surveys on inhibiting cataracts did not reach the consensus. Confounding factors, such as individual differences and the changes in amount of daily intake, may interfere with the results. We investigated the changes in oxidative status after administering supplement which containing determined dose of antioxidants by measuring samples from patients with identical grades of cataracts in both eyes. By this method, the individual differences and the changes in daily intake can be controlled. Aqueous humor and the lenticular anterior capsule samples were collected during cataract surgery before six-week oral administration of Ocuvite+Lutein®, an antioxidant supplement, as pre-intake. Post-intake samples were collected with the same method during cataract surgery of the opposite eye after the supplementation. The superoxide scavenging activity increased while total hydroperoxides decreased in aqueous humor after the supplementation. In the lenticular anterior capsule, the expression of glucose-6-phosphate dehydorgenase, a rate-determining enzyme of the pentose phosphate cycle, and 18S rRNA, related to protein synthesis in ribosome, increased. On the other hand, the expression of Aquaporin 8, a diffusion facilitator of hydrogen peroxide, decreased. According to the results of this study, the lutein-containing supplement suppresses the oxidation in the lens, and the potential in preventing the onset and the progression of cataracts was suggested.

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© 2018 Japanese Society for Cataract Research
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