Individuality of cerebral blood flow autoregulation in rats confirmed by mathematical model simulation of brain blood vessels

Abstract

Several reports showed cerebral blood flow (CBF) autoreguration was not persistent. The individual responses of autoreguration in rats might be interpreted by a mathematical model of rat brain blood vessels. We have run a simulation of the mathematical model reported by Ursino. The parameters of the simulation were fitted for experimental results on rats. The simulation shows a variation of CBF autoregulation with a parameter of arteriole in the physiological range. It might be indicated CBF autoregulatory curve was distinct in rats.