2015 Volume 26 Issue 2 Pages 245-251
15O-labeled gas PET has been performed in clinical settings for over 20 years, the stage classification by Powers has been widely used as a basic theory. However, some cases were unable to classified into any category by Powers in clinical practices. Especially, there has been no comprehensive report about paradoxical reduction after acetazolamide loading. We evaluated the brain regions with paradoxical reduction and demonstrated that high blood f low regions were included in them. Furthermore, we have established the method of quantitative evaluation of cerebral blood flow and oxygen metabolism in small animals by 15O-labeled gas PET and successfully performed the PET imaging of increased OEF in the ischemia model. 15O-labeled gas PET and glial PET imaging are expected to bridge between disease models and clinical pathology with the evaluation of cerebral circulation and metabolism.
