A guinea pig with skin-like heteroplasia in the right cornea was found in a stock of the Hartley strain. Histological examination showed that a part of the corneal epithelium together with the anterior half of the corneal stroma was re-placed with a skin-like structure but the posterior half of the stroma and corneai endothelium remained intact. The pathogenesis of this heteroplasia is discussed from the point of corneal morphogenesis, with special reference to epithelial-mesenchymal interaction.
