ChemoBio Integrated Management
Online ISSN : 1349-9041
ISSN-L : 1349-9041
special issue
Effects on the Behavior and Neural Symptoms of Male Mice Administrated Extract of Commercially Distributed Hawaiian Wood Rose Seed
Nobutaka FUKUMORIHiroshi ANDOYoshikazu KUBOKatsuhiro YUZAWAAkemichi NAGASAWAHiroshi TAKAHASHINorio YANOTatsu FUWANorio OHASHIAkio OGATA
Author information
JOURNAL FREE ACCESS

2010 Volume 6 Issue 1 Pages 58-65

Details
Abstract

The Tokyo Metropolitan Government enacted an ordinance on illegal drug abuse prevention. As a result, plant-derived drugs, rather than chemical drugs, have been dominating the market. Extract of commercially distributed Hawaiian wood rose seed containing lysergic acid alkaloids was administered by gavage to mice, and the neuro-behavior of these animals was observed using the screening method that has been developed in our laboratory. In the high dose group, head twitching, sedation, increased sound response, and reinforcement of pain response and tendon reflex were observed. These results suggest that an alteration in the serotonin level in the brain is involved in these changes.

Content from these authors
© 2010 by ChemoBio Integrated Management Society
Previous article Next article
feedback
Top