2010 Volume 6 Issue 1 Pages 58-65
The Tokyo Metropolitan Government enacted an ordinance on illegal drug abuse prevention. As a result, plant-derived drugs, rather than chemical drugs, have been dominating the market. Extract of commercially distributed Hawaiian wood rose seed containing lysergic acid alkaloids was administered by gavage to mice, and the neuro-behavior of these animals was observed using the screening method that has been developed in our laboratory. In the high dose group, head twitching, sedation, increased sound response, and reinforcement of pain response and tendon reflex were observed. These results suggest that an alteration in the serotonin level in the brain is involved in these changes.