Abstract
Clinical and bacteriological studies were made on pipemidic acid (PPA) in 17 patients suffering from urinary tract infections.
The results were as follows.
1) MICs of PPA against 30 strains of Pseudomonas aeruginosa were distributed in the range of 12.5μg/ml to 100μg/ml, and the peak of MIC was 25μg/ml.
2) Against E. coli, MICs of PPA were distributed in the range of 3.13μg/ml to more than 200μg/ml and the peak was 3.13μg/ml.
3) The antibacterial activity of PPA against Pseudomonas aeruginosa was found to be approximately comparable to or higher than that of P-CBPC and I-CBPC.
4) No remarkable side effects to be mentioned were observed.
