Abstract
The chronic toxicity of T-1220 was tested in beagle dogs using the intravenous ad-ministration, and compared with that of aminobenzylpenicillin (ABPC). Dogs were administered in daily intravenous doses of T-1220 for 6 months at 500, 1, 000 and 2, 000 mg/kg. ABPC was used at 2, 000 mg/kg. Control dogs were treated with physiological saline.
The results are as follows.
1) 1 (male) out of 5 dogs of T-1220 at 1, 000 mg/kg and 2 (male) out of 7 dogs of ABPC died or were killed because of debility during the experimental period.
2) The significant change of body weight was not seen in all dogs alive.
3) In 1 (male) out of 7 dogs of T-1220 at 2, 000 mg/kg, decreases of RBC, hemoglobin and hematocrit values, increase of LDH value and slight increases of kidney and liver weights were observed.
4) The megakaryocyte of spleen increased, histologically, in dogs treated with T-1220 at 2, 000 mg/kg.
5) The injury of injection site of T-1220 was milder than that of ABPC.
6) The maximum safety dose of intravenous administration of T-1220 to dogs estimated to be 500 mg/kg in male and 1, 000 mg/kg in female.
