CHEMOTHERAPY
Online ISSN : 1884-5894
Print ISSN : 0009-3165
ISSN-L : 0009-3165
FUNDAMENTAL AND CLINICAL STUDIES OF CEFUROXIME IN THE FIELD OF OBSTETRICS AND GYNECOLOGY
ZENJIRO TAKASEHIROKO SHIROFUJIMASAHIRO UCHIDA
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1979 Volume 27 Issue Supplement6 Pages 600-602

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Abstract

New synthetic cephalosporin cefuroxime (CXM) was studied on various transfer levels between mother and fetus and on clinical efficacy.
CXM concentration in umbilical cord blood reached a peak about 30 minutes later than in maternal blood and its peak value was about 1/4 of that in maternal blood. CXM concentration in amniotic fluid reached a peak more slowly, with a tendency toward retention in 8 hours after CXM treatment. In neonate CXM showed low blood levels, though with a tendency toward retention in blood in 24 hours after CXM treatment. Fetal levels of CXM, transferred from mother in the early stage of pregnancy, were higher than maternal levels, and higher concentration was noticed particularly in kidney. Transfer of CXM to maternal milk was rather moderate, compared with the conventional antibiotics.
The clinical results of CXM were effective in 3 out of 4 cases; the therapy was discontinued in the remaining 1 case due to nausea and vomiting.

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© Japanese Society of Chemotherapy
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