Abstract
This study was performed to evaluate the degree of irritative activity resulting from an intramuscular injections of 6059-S, in comparison with those of cefamandole, cephalothin, cefazolin and cephaloridine.
In the first experiment, 6059-S and the other cephalosporins were dissolved in distilled water to make a 25%(w/v) solution.Injections of one ml of the solution were made into the erector spinae muscle of japanese white female rabbits. The rabbits were sequentially killed 2, 7, 14 and 28 days later and the muscle sites were excised and placed in formalin fixative for 72 hours after gross examination.Sectioning of the fixed tissue permitted a measurement of the volume of irritation.A representative section of the irritated area was examined histopathologically.
The irritative action of 6059-S was slightly more severe than those of cephaloridine and cefazolin, almost the same as that of cefamandole and relatively less than that of cephalothin. The animals given 6059-S had recovered from the irritation at 28 days after the injection.But, in the animals injected 6059-S daily for 5 or 10 days, the irritative changes still remained by 28 days after the injection.
In the second experiment, 6059-S was dissolved in a local anesthetic, 0.5% lidocaine hydrochloride, to reduce pain on intramuscular injection and compared the irritation with that of 6059-S dissolved in distilled water.No difference in local irritative action was observed between 6059-S dissolved in distilled water and 6059-S dissolved in lidocaine hydrochloride.
