Penetration of SY 5555 into female genital tissues

Abstract

The Penetration of SY 5555, a new oral penem antibiotic, into female genital tissues was examined. SY 5555 was orally administered at a dose of 100 mg, 200 mg or 300 mg to 91 patients undergoing total hysterectomy. After administration of SY 5555, cubital vein blood, uterine artery blood and female genital organs were obtained. The concentration of drug was determined by bioassay method. Serum concentration in the uterine artery was the same as that in the cubital vein. The mean maximal serum concentration was 1.1μg/ml at 60-120 minutes after administration of 200 mg. The peak levels in various tissues of genital organs were obtained at 60-120 minutes, the mean levels in the portio vaginalis, oviduct, cervix uteri, myometrium, endometrium and ovary were 0.43μg/g, 0.35μg/g, 0.33μg/g, 0.26μg/g, 0.24μg/g and 0.21μg/g, respectively, after administration of 200 mg. The ratios of these tissues to serum concentration in the cubital vein ranged from 20.9% to 44.8%. Thus, SY 5555 rapidly penetrates into the female genital tissues, and we consider SY 5555 to be one of the most useful drugs for infections in the field of obstetrics and gynecology.