Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Special Article
Progress in Myocardial Regeneration and Cell Transplantation
Keiichi Fukuda
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2005 Volume 69 Issue 12 Pages 1431-1446

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Abstract

Embryonic stem cells and bone marrow mesenchymal stem cells can be induced to differentiate into cardiomyocytes. Techniques to purify and transplant regenerated cardiomyocytes have been developed, and transplanted regenerated cardiomyocytes are capable of residing in the heart of recipients for long periods. Advances in tissue engineering technology have enabled the production of cardiomyocyte cell sheets for transplantation treatment of heart failure, without the need for a donor, and this has now reached the preclinical stage. The treatment of heart failure using cytokines to mobilize stem cells has also been explored. (Circ J 2005; 69: 1431 - 1446)

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© 2005 THE JAPANESE CIRCULATION SOCIETY
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