Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Intracoronary Continuous Adenosine Infusion
A Novel and Effective Way of Inducing Maximal Hyperemia for Fractional Flow Reserve Measurement
Bon-Kwon KooCheol-Ho KimSang-Hun NaTae-Jin YounIn-Ho ChaeDong-Ju ChoiHyo-Soo KimMyoung-Mook LeeByung-Hee OhYoung-Bae ParkYun-Shik ChoiSeung-Jae Tahk
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2005 Volume 69 Issue 8 Pages 908-912


Background Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. Methods and Results Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 μg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 μg/min) with IC bolus injection (40, 80 μg) and intravenous (IV) infusion (140 μg · kg -1 · min-1) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p=0.06). In the phase II study, FFR after an IC bolus injection (0.83±0.06) was significantly higher than with IV (0.79±0.07) or IC (0.78±0.09) infusion (p<0.01). However, no difference in FFR was observed for IC and IV infusions. Conclusion IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement. (Circ J 2005; 69: 908 - 912)

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