Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Clinical Investigation
Sex Differences in Early Mortality of Patients Undergoing Primary Stenting for Acute Myocardial Infarction
Masami KosugeKazuo KimuraSunao KojimaTomohiro SakamotoMasaharu IshiharaYujiro AsadaChuwa TeiShunichi MiyazakiMasahiro SonodaKazufumi TsuchihashiMasakazu YamagishiYoshihiko IkedaMutsunori ShiraiHisatoyo HiraokaTakeshi InoueFumio SaitoHisao Ogawaon behalf of the Japanese Acute Coronary Syndrome Study (JACSS) Investigators
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2006 Volume 70 Issue 3 Pages 217-221


Background Limited information exists regarding the impact of gender on in-hospital outcome after primary stenting for acute myocardial infarction (AMI). Methods and Results A total of 2,981 patients (790 women and 2,191 men) participated in the study who were admitted within 24 h after symptom onset and underwent emergency primary stenting for AMI. Compared with men, women were significantly older; had higher incidences of hypertension, diabetes mellitus, hyperlipidemia, Killip class ≥2, and cardiogenic shock; had a higher blood glucose level and a lower serum creatinine level on admission. Other baseline characteristics, including the incidences of ST-segment elevation AMI, anterior infarction, 3-vessel disease, initial or final Thrombolysis in Myocardial Infarction (TIMI) flow grade did not significantly differ between the sexes. The in-hospital mortality rate was significantly higher in women than in men (9.4% vs 5.2%, p<0.001). On multivariate analysis, age, Killip class, blood glucose level, serum creatinine level, and final TIMI grade were independent predictors of in-hospital death, but female gender was not (odds ratio 1.01, p=0.69). Conclusions Our findings suggest that in patients undergoing primary stenting for AMI, women have higher in-hospital mortality than men, but female gender itself is not independently associated with increased in-hospital mortality after adjustment for baseline differences. (Circ J 2006; 70: 217 - 221)

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