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Circulation Journal
Vol. 70 (2006) No. 5 p. 572-574

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http://doi.org/10.1253/circj.70.572

Clinical Investigation

Background The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA). Methods and Results Polysomnography was performed in 105 CHF patients. Twenty-six patients with CHF and SA were randomly assigned to a control group or a PPV group. Patients in the higher New York Heart Association classes had higher plasma levels of NT-proBNP. The plasma NT-proBNP concentration in the PPV group decreased. Conclusion Plasma NT-proBNP levels reflect the severity of CHF, and PPV can decrease plasma NT-proBNP levels in patients with CHF and SA. (Circ J 2006; 70: 572 - 574)

Copyright © 2006 THE JAPANESE CIRCULATION SOCIETY

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