Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Effect of Autologous Bone-Marrow Cell Transplantation on Ischemic Ulcer in Patients With Buerger's Disease
Yutaka SaitoKen-ichiro SasakiYousuke KatsudaToyoaki MuroharaYoshiaki TakeshitaTeiji OkazakiKen ArimaYoshio KatsukiSatoshi ShintaniToshifumi ShimadaHidetoshi AkashiHisao IkedaTsutomu Imaizumi
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2007 Volume 71 Issue 8 Pages 1187-1192

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Abstract

Background Thromboangiitis obliterans, also known as Buerger's disease, is characterized by peripheral occlusive changes in the arteries of the upper and lower limbs and treatment is often ineffective. Intramuscular transplantation of autologous bone marrow-mononuclear cells (BM-MNC) has been recently reported as improving the symptoms and clinical manifestations in patients with severely ischemic limbs, mostly caused by arteriosclerosis obliterans. The present study focused on the patients with Buerger's disease presenting with rest pain and/or skin ulcer uncontrolled by conventional treatments. Methods and Results Fourteen patients with Buerger's disease (Fontaine III: n=2, Fontaine IV: n=12) underwent transplantation of autologous BM-MNC into ischemic skeletal muscles of either the upper or lower limb. After 4 weeks, rest pain was significantly reduced. In 19 skin ulcers of 9 patients, 8 ulcers were healed and 8 were diminished in the size. These improvements were maintained for 24 weeks without complications. Conclusions In patients with Buerger's disease, intramuscular transplantation of autologous BM-MNC improved symptoms and clinical manifestations, especially skin ulcer. (Circ J 2007; 71: 1187 - 1192)

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© 2007 THE JAPANESE CIRCULATION SOCIETY
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