Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Vascular Medicine
N-Acetylcysteine Reduces the Severity of Atherosclerosis in Apolipoprotein E-Deficient Mice by Reducing Superoxide Production
Kana ShimadaToshinori MurayamaMasayuki YokodeToru KitaHiroyasu UzuiTakanori UedaJong-Dae LeeChiharu Kishimoto
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2009 Volume 73 Issue 7 Pages 1337-1341

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Abstract

Background: Oxidative stress may play an important role in the development of atherosclerosis. Because N-acetylcysteine (NAC) is able to reduce oxidative stress, the present study assessed the hypothesis that NAC may reduce the severity of atherosclerosis in apolipoprotein (apo) E-deficient mice. Methods and Results: Atherosclerosis was induced in apoE-deficient mice fed a high-fat diet containing 0.3% cholesterol. Mice were injected intraperitoneally with NAC (20 mg · kg-1 · day-1) 3 times per week over 8 weeks. Fatty streak plaque developed in the apoE-deficient mice, but not in mice treated with NAC. In addition, NAC reduced superoxide production in the aortic walls, as detected by ethidium staining. NAC treatment did not significantly modify the serum lipid profiles. Conclusions: In this animal model NAC may suppress atherosclerosis via reducing superoxide production. (Circ J 2009; 73: 1337-1341)

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© 2009 THE JAPANESE CIRCULATION SOCIETY
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