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Circulation Journal
Vol. 74 (2010) No. 11 p. 2249-2256

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http://doi.org/10.1253/circj.CJ-10-0904

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Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms. (Circ J 2010; 74: 2249-2256)

Copyright © 2010 THE JAPANESE CIRCULATION SOCIETY

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