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Circulation Journal
Vol. 74 (2010) No. 6 p. 1257-1259

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http://doi.org/10.1253/circj.CJ-10-0189

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Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.  (Circ J 2010; 74: 1257 - 1259)

Copyright © 2010 THE JAPANESE CIRCULATION SOCIETY

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