Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Reviews
Endothelial Loss and Repair in the Vascular Complications of Diabetes
– Pathogenetic Mechanisms and Therapeutic Implications –
Richard E. Gilbert
Author information
JOURNALS FREE ACCESS

2013 Volume 77 Issue 4 Pages 849-856

Details
Abstract

Although seemingly diverse, the tissue injury at sites of diabetic complications, whether in the heart, kidneys or eyes, shares the common histopathological feature of endothelial cell loss, a consequence of both increased cell death and deficient regeneration. In medium-sized and larger arteries the loss of the protective lining contributes to the atherosclerotic process, while at sites of microvascular disease endothelial cell loss leads to capillary rarefaction and ischemia. The pathophysiology of these changes and their consequences on organ structure and function in diabetes are reviewed, and the potential for endothelial regenerative strategies to enhance repair and ameliorate the long-term complications of diabetes is explored.  (Circ J 2013; 77: 849–856)

Information related to the author
© 2013 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top