Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Cardiovascular Intervention
High Mortality Rate in Hemodialysis Patients Who Undergo Invasive Cardiovascular Procedures Related to Peripheral Artery Disease – Community-Based Observational Study in Kumamoto Prefecture –
Seiji HokimotoKenji SakamotoTomonori AkasakaKoichi KaikitaOsamu HondaMasahiro NaruseHisao Ogawafor the Multi-center Study of Hemodialysis Patients Undergoing Invasive Cardiovascular Procedures Study Investigators
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2015 Volume 79 Issue 6 Pages 1269-1276

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Abstract

Background:Cardiovascular disease is a major cause of mortality in hemodialysis patients. The aim was to assess the relationship of various invasive cardiovascular procedures (ICP) to clinical outcome in hemodialysis patients.Methods and Results:A total of 5,813 patients at 76 facilities were on maintenance hemodialysis in Kumamoto Prefecture. Of these, 4,807 patients at 58 institutions were enrolled. Of 4,807 patients, 212 ICP (4.4%) were performed for various cardiovascular diseases in 189 patients (3.9%). ICP included PCI (n=80), endovascular treatment (n=59), radiofrequency catheter ablation (n=8), implantation of permanent pacemaker (n=15) and ICD (n=5), thoracotomy for valvular diseases (n=16), CABG (n=14), bypass surgery for peripheral artery disease (PAD; n=8), and artificial vessel replacement for aneurysm or aortic dissection (n=7). The overall mortality rate was 10.1% (19/189 patients). The mortality rate was highest in patients who underwent ICP for PAD, compared with other ICP (PAD, 18.2%; non-PAD, 6.7%, P=0.017). Infection and PAD were significant predictors of mortality (infection: OR, 8.30; 95% CI: 1.29–65.13, P=0.027; PAD: OR, 3.76; 95% CI: 1.35–10.48, P=0.012). The presence of inflammation/malnutrition factors was associated with high mortality (OR, 15.49; 95% CI: 3.22–74.12, P=0.0006).Conclusions:In this community-based registry study of 4,807 hemodialysis patients, the mortality rate of PAD patients was high despite ICP. (Circ J 2015; 79: 1269–1276)

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© 2015 THE JAPANESE CIRCULATION SOCIETY
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