Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Cardiovascular Intervention
Temporal Trends in Clinical Outcome After Percutaneous Coronary Intervention 1984–2010 – Report From the Juntendo PCI Registry –
Ryo NaitoKatsumi MiyauchiHirokazu KonishiShuta TsuboiManabu OgitaTomotaka DohiTakatoshi KasaiHiroshi TamuraShinya OkazakiKikuo IsodaHiroyuki Daida
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2016 Volume 80 Issue 1 Pages 93-100


Background:Since the introduction of PCI in 1977, it has evolved along with advances in the technology, improvement in operator technique and establishment of medical therapy. However, little is known of the improvement in clinical outcome following PCI.Methods and Results:Data from the Juntendo PCI Registry during 1984–2010 were analyzed. The patients were divided into 3 groups according to date of index PCI: POBA era, January 1984–December 1997; BMS era, January 1998–July 2004; and DES era, August 2004–February 2010. The primary endpoint was a composite of MACE including all-cause mortality, non-fatal MI, non-fatal stroke and revascularization. A total of 3,831 patients were examined (POBA era, n=1,147; BMS era, n=1,180; DES era, n=1,504). Mean age was highest in the DES era. The prevalence of diabetes and hypertension was higher in the DES and BMS eras than in the POBA era. Unadjusted cumulative event-free survival rate for 2-year MACE was significantly different across the 3 eras. Adjusted relative risk reduction for 2-year MACE was 56% in the DES era and 34% in the BMS era, both compared with the POBA era. Age, ACS, and LVEF were associated with the incidence of MACE.Conclusions:Clinical outcome of PCI improved across the 26-year study period, despite the higher patient risk profile in the recent era. (Circ J 2016; 80: 93–100)

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