Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　– First-in-Human Pilot Study –

Tomoyoshi Tamura; Kei Hayashida; Motoaki Sano; Masaru Suzuki; Takayuki Shibusawa; Joe Yoshizawa; Yosuke Kobayashi; Takeshi Suzuki; Shigeo Ohta; Hiroshi Morisaki; Keiichi Fukuda; Shingo Hori

doi:10.1253/circj.CJ-16-0127

Rapid Communication

Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　– First-in-Human Pilot Study –

Tomoyoshi Tamura, Kei Hayashida, Motoaki Sano, Masaru Suzuki, Takayuki Shibusawa, Joe Yoshizawa, Yosuke Kobayashi, Takeshi Suzuki, Shigeo Ohta, Hiroshi Morisaki, Keiichi Fukuda, Shingo Hori

Author information

Tomoyoshi Tamura
Department of Emergency and Critical Care Medicine, Keio University School of Medicine
The Center for Molecular Hydrogen Medicine, Keio University
Kei Hayashida
Department of Emergency and Critical Care Medicine, Keio University School of Medicine
The Center for Molecular Hydrogen Medicine, Keio University
Motoaki Sano
Department of Cardiology, Keio University School of Medicine
The Center for Molecular Hydrogen Medicine, Keio University
Masaru Suzuki
Department of Emergency and Critical Care Medicine, Keio University School of Medicine
The Center for Molecular Hydrogen Medicine, Keio University
Takayuki Shibusawa
Department of Emergency and Critical Care Medicine, Keio University School of Medicine
Joe Yoshizawa
Department of Emergency and Critical Care Medicine, Keio University School of Medicine
Yosuke Kobayashi
Department of Emergency and Critical Care Medicine, Keio University School of Medicine
Takeshi Suzuki
Department of Anesthesiology, Keio University School of Medicine
Shigeo Ohta
Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School
Hiroshi Morisaki
Department of Anesthesiology, Keio University School of Medicine
Keiichi Fukuda
Department of Cardiology, Keio University School of Medicine
Shingo Hori
Department of Emergency and Critical Care Medicine, Keio University School of Medicine

Keywords: Hydrogen gas inhalation, Molecular hydrogen, Post-cardiac arrest syndrome, Return of spontaneous circulation

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Supplementary material

2016 Volume 80 Issue 8 Pages 1870-1873

DOI https://doi.org/10.1253/circj.CJ-16-0127

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Details

Abstract

Background:Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.

Methods and Results:Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome.

Conclusions:HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870–1873)

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