Circulation Journal
Rapid Communication
Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms
Deborah A. HowattMaya DajeeXiaojie XieJessica MoorleghenDebra L. RateriAnju BalakrishnanValdeci Da CunhaDouglas G. JohnsDavid E. GutsteinAlan DaughertyHong Lu
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Volume 81 (2017) Issue 6 Pages 888-890

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Abstract

Background:This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).

Methods and Results:Male C57BL/6 or apolipoprotein E−/−mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E−/−mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence.

Conclusions:MMP-9 deficiency augmented AngII-induced AAA.

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© 2017 THE JAPANESE CIRCULATION SOCIETY
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