Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Rivaroxaban in Clinical Practice for Atrial Fibrillation With Special Reference to Prothrombin Time
Shinya SuzukiTakayuki OtsukaKoichi SagaraHiroto KanoShunsuke MatsunoYuko KatoHideaki TakaiTokuhisa UejimaYuji OikawaKazuyuki NagashimaHajime KirigayaJunji YajimaHitoshi SawadaTadanori AizawaTakeshi Yamashita
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JOURNALS FREE ACCESS Advance online publication

Article ID: CJ-13-1380

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Abstract

Background: Prothrombin time (PT) distribution in Japanese nonvalvular atrial fibrillation (NVAF) patients under rivaroxaban therapy remains to be clarified. Methods and Results: Between May 2012 and July 2013, 115 NVAF patients received rivaroxaban (PT was measured in 94; reagent: recombiplastin). In these patients, (1) PT values were distributed widely from patient to patient and from peak to trough, (2) the time-dependence was obscure with sampling at any time in the outpatient clinic, and (3) the incidence of adverse events was too low for analyzing the relation with PT. Conclusions: We report the distribution of PT for Japanese NVAF patients under rivaroxaban therapy in real-world clinical practice.

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© 2014 THE JAPANESE CIRCULATION SOCIETY
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