Abstract
For the determination of the best condition for the practical application of a plasma substitute, alginic acid, introduced by Professor Tomoda, the Author made a series of experiments on the water content, viscosity and the colloid osmotic pressure of the serum by injecting this acid of various concentrations intravenously into the rabbit made anemic by artificial hemorrhage, and arrived at the following conclusions : The theoretical concentrations based on the colloid chemistry lie between 1 and 1,5%. In the practical application however, some side effects appear by these concentrations. The concentration of 0.3% has a considerable capacity for holding water in the serum, while the dilution over 0.6% calls forth some ill effects in the biological properties of the individual. The concentration of 0.3% and the relative viscosity of 2 would therefore be the bast condition in the practical application.
