DEVELOPMENT OF SUBSTRAINS IN SPONTANEOUSLY HYPERTENSIVE RATS: GENEALOGY, ISOZYMES AND EFFECT OF HYPERCHOLESTEROLEMIC DIET

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Genealogical study and experimental fat-cholesterol and salt loadings showed that the present strain (F_26-27) of spontaneously hypertensive rats consisted of several substrains with no difference in the level of blood pressure but with a marked difference in the incidence of cardiovascular lesions. Biochemical specificities of these substrains were demonstrated by ALPase and esterase isozymes in the liver and serum. Different responses in serum cholesterol level to the hypercholesterolemic diet served as a further differentiation of some lines among these substrains and were seemingly related to their vulnerability to cardiovascular lesions under these experimental conditions.