1973 Volume 37 Issue 5 Pages 497-508
Alkaline phosphatase activity of mesenteric arteries was markedly increased in spontaneously hypertensive rats (SHR) compared to normotensive rats (NR). The aorta showed almost the same tendency, but was not so remarkable as mesenteric arteries. Furthermore, a positive correlation between alkaline phosphatase activity of mesenteric arteries and the blood pressure level was observed in the F2 segregate generation. Slight but significantly high enzymatic activities were also detected in acid phosphatase of the aorta, in glucose-6-phosphate dehydrogenase of the aorta and in lactic dehydrogenase of the heart in SHR. In addition to these findings, differences in the electrophoretic pattern of esterase isozymes of mesenteric arteries and the aorta between SHR and NR were detected. These enzymological abnormalities in the cardiovascular system, especially mesenteric arteries, might have some relationship to the development and/or the maintenance of genetic hypertension in SHR.
