JAPANESE CIRCULATION JOURNAL
CARDIOVASCULAR EFFECTS OF ISOPROTERENOL AND POSSIBLE ANTAGONISTIC ACTIONS OF PROPRANOLOL AND PERHEXILINE
HIDEHIKO MATSUKAWAEIICHIRO OKABEHARUHIKO SAKAMOTOYOUNG W. CHOHARUO ITO
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Volume 42 (1978-1979) Issue 4 Pages 425-432

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Abstract

A beta-adrenergic blocking activity of perhexiline was compared with that of propranolol. In the Langendorff's preparation of rabbits, canine heart-lung preparation, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effectively blocked by propranolol. These data suggest that perhexiline is not a beta-adrenergic receptor blocking agent.

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© Japanese Circulation Society
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