The Effects of M-protein Fraction of Hemolytic Streptococci on Embryonic Heart in the Rat : THE 9th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE

KOICHIRO MIYATA; TAMOTSU JITOSHO; TETSUO TAKESUE; SHUZO MUNAKATA; SEIGO ONO; EIJI YAMAMOTO; KIYOSHI KAWAKAMI; TAMOTSU TERAWAKI

doi:10.1253/jcj.49.1265

KOICHIRO MIYATA, TAMOTSU JITOSHO, TETSUO TAKESUE, SHUZO MUNAKATA, SEIGO ONO, EIJI YAMAMOTO, KIYOSHI KAWAKAMI, TAMOTSU TERAWAKI

著者情報

キーワード: Experimental teratology, M-protein of hemolytic streptococci, Cardiovasucular malformations

ジャーナルフリー

1985 年 49 巻 12 号 p. 1265-1267

DOI https://doi.org/10.1253/jcj.49.1265

詳細

抄録

Wistar rats were administered M-protein fraction (MP) of group A type 12 hemolytic streptococci on day 9 of gestation. When 9 mg/kg of MP was injected, the incidence of malformations was 11.8%, and the incidence of cardiovascular malformations was 7.9%. The main malformations were ventricular septal defect, microphthalmia, and hydrocephaly. Light and electron microscopic studies revealed no myocarditis nor endocarditis in either the maternal or fetal heart. Fluorescent antibody technique demonstrated no immunological cross-reaction between MP and rat heart tissue. the results suggest that MP is slightly teratogenic in the rat.

責任著者(Corresponding author)

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