Name : [in Japanese]
Date : July 16, 2018 - December 23, 2018
In patients with type 2 diabetes mellitus (T2DM), maximum oxygen uptake and anaerobic threshold (AT) was decreased in comparison with that of a healthy population. It was reported that Homeostasis model assessment of insulin resistance (HOMAIR) was associated with maximum oxygen uptake in patients with T2DM. However, no studies have assessed the relationship between AT and HOMAIR. The purpose of this study was to examine the characteristic differences, especially AT differences between patients with T2DM whose HOMAIR was high and those whose HOMAIR was normal.
Of the patients with T2DM who underwent CPX at our hospital, those without insulin treatment and fasting plasma glucose (FPG) ≧ 140 mg/dL were included as study subjects. AT was evaluated using the V-slope method. %AT was calculated in comparison with the standard value of the Japanese Circulation Association. High HOMAIR and normal HOMAIR groups were defined as HOMAIR is higher than 1.6 and lower than 1.6, respectively. We compared the age, BMI, diabetic complication, drug therapy, HbA1c, FPG, CPI, %AT, knee extension power, body skeletal muscle percentage (%muscle) and body fat percentage (%fat) between high HOMAIR and normal HOMAIR groups using t-test. A software package (IBM SPSS Ver. 22) was used with a significance level at <5% for statistical analysis.
The following characteristics were observed in patients in the high HOMAIR(n=27) group as compared with those in the normal HOMAIR(n=16) group with statistically significant difference: higher BMI (p ＜ 0.01), higher CPI (p ＜ 0.05), higher %fat (p ＜ 0.01), lower %AT (p ＜ 0.05), lower %muscle (p ＜ 0.05). No significant difference was observed in age, diabetic complication, drug therapy, HbA1c, FPG, knee extension power.
In patients with T2DM, high HOMAIR decreased aerobic fitness.
This study was approved by the Study Ethical Review Board of Kansai electric power hospital under No. 28-15. All subjects gave informed consent for their participation in the study.