Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Oligoribonucleotide Synthesis By Use of the [[2-(Methylthio)phenyl]thio]methyl (MPTM) Group as the 2′-Hydroxyl Protecting Group
Mitsuo SekineTakashi Nakanishi
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1991 Volume 20 Issue 1 Pages 121-124

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Abstract

A new 2′-hydroxyl protecting group, [[2-(methylthio)phenyl]thio]methyl (MPTM), was introduced via a three-step reaction into the 2′-position of uridine and cytidine units required for the synthesis of oligoribonucleotides in the phosphotriester approach. By using these monomer building blocks, CpUpG was synthesized.

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© 1991 The Chemical Society of Japan
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