Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Fine Control of Regioselectivity in the Reduction of NAD+ Analogues by Ketene Silyl Acetals
Shunichi FukuzumiMorifumi FujitaSouta NouraJunzo Otera
Author information
JOURNALS RESTRICTED ACCESS

1993 Volume 22 Issue 6 Pages 1025-1028

Details
Abstract

Various NAD+ analogues are reduced regioselectively by ketene silyl acetals to afford the corresponding 2-, 6-, or 4-alkylated NADH analogues. The regioselectivity of the 1,2- (or 1,6-) vs. 1,4-reduction is finely controlled by the β-methyl-substitution of ketene silyl acetals, the position of methyl-substitution of NAD+ analogues, and the addition of Et4NCl or Bu4NF.

Information related to the author

This article cannot obtain the latest cited-by information.

© 1993 The Chemical Society of Japan
Previous article Next article
feedback
Top