Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
An Improved Purification Method for the Rapid Synthesis of High Purity Fluorobutyrophenone Neuroleptics from Nitro and Chloro Precursors Suitable for PET Study
Kazunari HashizumeNaoto HashimotoDavid G. CorkYoshihiro Miyake
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1994 Volume 23 Issue 12 Pages 2295-2298

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Abstract

A rapid micro-scale synthesis of fluorinated neuroleptics with extremely high chemical purity was accomplished using a new single column reverse-phase HPLC purification procedure that employs a strongly alkaline eluent to clearly separate F-labeled compounds from the large excess of nitro or chloro precursor. The method is applicable to the production of 18F-labeled positron emission tomography (PET) tracers with high specific activity.

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© 1994 The Chemical Society of Japan
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