Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Efficient Amounts of Additives for Peptide Coupling Mediated by a Water-Soluble Carbodiimide in Aqueous Media
Sukekatsu Nozaki
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1997 Volume 26 Issue 1 Pages 1-2

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Abstract

The optimal amounts of HOBt, HOSu, and HONb for enhancement of peptide coupling mediated by EDC in aqueous media were found to be less then equimolar against the C-component or the carbodiimide. A combination of EDC and 0.1 equimolar amount of HOBt was shown to be an effective coupling reagent under aqueous conditions.

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© 1997 The Chemical Society of Japan
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