Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Enzyme-Catalyzed P-F Bond Hydrolysis of Monofluorophosphate as a Simple Model of Sarin Detoxification
Norimasa YozaSachiko NakashimaTetsuya Nakazato
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1997 Volume 26 Issue 1 Pages 53-54

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Abstract

The catalytic ability of alkaline phosphatase (EC3.1.3.1) to promote P-F bond hydrolysis was examined with a simple nontoxic P-F compound, monofluorophosphate (Na2PO3F), to obtain an insight into the enzymatic degradation of Sarin, a toxic P-F compound. The enzyme recognized inorganic monofluorophosphate as a substrate and accelerated its hydrolytic conversion to orthophosphate and fluoride ions at pH 7.2 - 9.0 and 30 °C by a factor of ten billion (1010).

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© 1997 The Chemical Society of Japan
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