Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Selection of RNA-binding Peptides Containing an Arg-rich Motif
Naohiko ShimadaReiko IwaseTetsuji YamaokaAkira Murakami
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2004 Volume 33 Issue 3 Pages 212-213

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Abstract

In order to create RNA-binding peptides, we designed peptides based on the sequence information of the RNA-binding proteins and selected them using affinity chromatography. The five peptides out of 42 peptides were efficiently selected. The selected peptides containing Asn and Arg could recognize the RNA structure with the binding pocket such as the internal loop or G•U wobble pair.

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© 2004 The Chemical Society of Japan
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