Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Effects of K5SiW11O39Co on Mitogenic Activity of Basic Fibroblast Growth Factor
Liwei SunQiang WuNing LiuCheng YangLiyan LiuZhiqiang LiuDaqing Zhao
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2004 Volume 33 Issue 3 Pages 298-299

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Abstract

The interaction between polyoxometalate (POM) of Keggin class (K5SiW11O39Co) and human basic fibroblast growth factor (bFGF) was studied by fluorescence and CD spectra. The results indicate that the binding of POM to bFGF causes conformational changes of bFGF. The cell proliferation assay showed that in lower molar ratios, POM stimulates mitogenic activity of bFGF; in higher molar ratios, POM inhibits the mitogenic activity of bFGF.

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© 2004 The Chemical Society of Japan
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