2005 Volume 34 Issue 3 Pages 354-355
This report describes a Triton X-100-assisted method to assemble small Au nanoparticles by DNA hybridization. The non-specific adsorption of oligonucleotides, which is most prevalent on small Au nanoparticle surface and interferes with the hybridization of complementary sequences, is overcome by shielding the Au nanoparticle with a Triton X-100 layer. Amine-modified oligonucleotides, but not thiol-modified oligonucleotides, are able to penetrate the X-100 shell to enable the hybridization of complementary DNA sequences.
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