Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Glucose-specific Sensing with Boronic Acid Utilizing Enzymatic Oxidation
Yasumasa KanekiyoHiroaki Tao
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2006 Volume 35 Issue 8 Pages 852-853

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Abstract

A novel sensing system for glucose-specific detection has been established based on a combination of a boronic acid and enzymes. To overcome the inherently low biding affinity of glucose toward boronic acids, glucose is converted into gluconic acid by the enzymatic reaction using glucose oxidase (GOx), and then complexed with a fluorescent boronic acid through the α-hydroxycarboxylate moiety. According to the present strategy, glucose concentration is exclusively determined among other saccharides in aqueous solutions.

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© 2006 The Chemical Society of Japan
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