Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Synthesis of Glaziovianin A: A Potent Antitumor Isoflavone
Ichiro HayakawaAkiyuki IkedoHideo Kigoshi
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2007 Volume 36 Issue 11 Pages 1382-1383

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Abstract

Glaziovianin A (1) is a novel isoflavone derivative isolated from the leaves of the Brazilian tree Astelia glazioviana. Glaziovianin A (1) showed cytotoxic activity and was suggested to be an inhibitor of tubulin polymerization. We achieved the total synthesis of glaziovianin A (1) by using the Suzuki–Miyaura coupling as a key step.

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© 2007 The Chemical Society of Japan
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