Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Synthesis and Properties of Novel Oligodeoxynucleotides Containing 6,3′-Methanodeoxyuridine
Tomohisa MoriguchiFumisada YamatoKazuo Shinozuka
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2008 Volume 37 Issue 5 Pages 548-549

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Abstract

This paper deals with the synthesis and properties of novel oligodeoxynucleotide containing 6,3′-methanodeoxyuridine which is connected between C-6 of pyrimidine base and C-3′ of deoxyribose by a methylene group. The modified base was successfully introduced into the oligodeoxynucleotide by the standard method. The modified oligodeoxynucleotide formed the less stable duplex with both complementary DNA and RNA. The CD spectra indicated that the duplex formed the noncanonical duplex structure distinct from the A-form or B-form structure.

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© 2008 The Chemical Society of Japan
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