Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
Letter
Detector-free and Multiple Sensing of Various Molecules Using Gold Nanoparticles and Aptazymes
Atsushi OgawaMizuo Maeda
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2009 Volume 38 Issue 8 Pages 848-849

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Abstract

We have developed a detector-free and multiple detection method for various analytes using some orthogonal pairs of cleavase-aptazymes and the corresponding probe-DNA-tethered gold nanoparticles (AuNPs) for each analyte. In this method, each cleavase-aptazyme cleaves itself only in the presence of its cofactor (i.e. analyte), and each resulting cleaved RNA hybridizes only to the corresponding probe DNA on AuNPs to induce AuNP aggregation that can be detected with the naked eye.

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© 2009 The Chemical Society of Japan
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