Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Selective Coupling at the α-Amino Group of Cysteine Using Transfer Active-ester-condensation Technology to Synthesize a Linear Octadecapeptide
Yongxiang LiaoYan KongNaifeng HuZhi JinPu Wang
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2010 Volume 39 Issue 3 Pages 196-197

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Abstract

The peptide segment Fmoc-Ubiquitin67–76-NHNH2 was converted to the active ester Fmoc-Ubiquitin67–76-OCt and reacted with an unprotected seven residue fragment (H-mNGF110–117-OH) from murine Nerve Growth Factor, which contains a Cys at the N-terminus and a free ε-amino group at Lys115, using transfer active-ester-condensation (TAEC) technology. The linear product H-Ubiquitin67–76-murine Nerve Growth Factor110–117-OH was formed exclusively through the native chemical ligation mechanism.

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© 2010 The Chemical Society of Japan
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